Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated

Wu, Chunmei; Fu, Qiong; Guo, Qiang; Chen, Sheng; Goswami, Shyamal; Sun, Shuhui; Li, Teng; Cao, Xingjian; Chu, Fuying; Chen, Zechuan; Liu, Mei; Liu, Yuanhua; Fu, Ting; Hao, Pei; Hao, Yi; Shen, Nan; Bao, Chunde; Zhang, Xiaoming

doi:10.1136/annrheumdis-2019-215039

Public

Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated

Published in Annals of the Rheumatic Diseases • May 29, 2019

Authors:

Chunmei Wu

Qiong Fu

Qiang Guo

Abstract

Objectives A population of atypical memory B cells (AtMs) are greatly expanded in patients with active lupus, but their generation and pathophysiological roles are poorly defined. The aim of this study was to comprehensively characterise lupus AtMs with a purpose to identify therapeutic clues to tar...

Subject

Systemic lupus erythematosus

Lupus nephritis

mTORC1

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