Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and <i>APOE</i> genotype

Vermunt, Lisa; A.M. Sikkes, Sietske; van den Hout, Ardo; Handels, Ron; Bos, Isabelle; M. van der Flier, Wiesje; Kern, Silke; Ousset, Pierre‐Jean; Maruff, Paul; Skoog, Ingmar; R.J. Verhey, Frans; Freund‐Levi, Yvonne; Tsolaki, Magda; K. Wallin, Åsa; G. M. Olde Rikkert, Marcel; Soininen, Hilkka; Spiru, L.; Zetterberg, Henrik; Blennow, Kaj; Scheltens, Philip; Muñiz‐Terrera, Graciela; Jelle Visser, Pieter; the Alzheimer Disease Neuroimaging Initiative, for; study groups, ICTUS/DSA

doi:10.1016/j.jalz.2019.04.001

Public

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Published in Alzheimer s & Dementia • Jun 1, 2019

Authors:

Lisa Vermunt

Sietske A.M. Sikkes

Ardo van den Hout

Abstract

INTRODUCTION: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. METHODS: We performed multistate modeling in a com...

Subject

Dementia

Apolipoprotein E

Genotype

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