CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Hu, Jinwei; Wang, Wei; Lan, Xiao-Liang; Zeng, Zhao‐Chong; Liang, Yingke; Yan, Yuhui; Song, Fuyao; Wang, Fangfang; Zhu, Xiaoxia; Liao, Wenting; Liao, Wenjie; Ding, Yanqing; Li, Liang

doi:10.1186/s12943-019-1019-x

Public

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Published in Molecular Cancer • May 7, 2019

Authors:

Jinwei Hu

Wei Wang

Xiao-Liang Lan

Abstract

BACKGROUND: Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and chemoresistance have not been fully characterized. METHODS: CAFs and NFs were obt...

Subject

Microvesicles

Epithelial–mesenchymal transition

Metastasis

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