Genome-wide cell-free DNA fragmentation in patients with cancer

Cristiano, Stephen; Leal, Alessandro; Phallen, Jillian; Fiksel, Jacob; Adleff, Vilmos; C. Bruhm, Daniel; Østrup Jensen, Sarah; E. Medina, Jamie; Hruban, Carolyn; R. White, James; N. Palsgrove, Doreen; Niknafs, Noushin; Anagnostou, Valsamo; M. Forde, Patrick; Naidoo, Jarushka; A. Marrone, Kristen; R. Brahmer, Julie; Woodward, Brian; Husain, Hatim; L. van Rooijen, Karlijn; W. Ørntoft, Mai‐Britt; Husted Madsen, Anders; J.�H. van de Velde, Cornelis; Verheij, Marcel; Cats, Annemieke; J. A. Punt, Cornelis; R. Vink, Geraldine; C.T. van Grieken, Nicole; Koopman, Miriam; J.A. Fijneman, Remond; S. Johansen, Julia; Jørgen Nielsen, Hans; A. Meijer, Gerrit; L. Andersen, Claus; B. Scharpf, Robert; E. Velculescu, Victor

doi:10.1038/s41586-019-1272-6

Public

Genome-wide cell-free DNA fragmentation in patients with cancer

Published in Nature • May 29, 2019

Authors:

Stephen Cristiano

Alessandro Leal

Jillian Phallen

Abstract

. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood c...

Subject

Fragmentation (computing)

Genome

DNA

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