Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

T. Roumenina, Lubka; V. Daugan, Marie; Noé, Rémi; Petitprez, Florent; Vano, Yann; Sanchez‐Salas, Rafael; Becht, Étienne; Meilleroux, Julie; Le Clec'h, Bénédicte; A. Giraldo, Nicolás; S. Merle, Nicolas; Sun, Cheng‐Ming; Verkarre, Virginie; Validire, Pierre; Sèlves, Janick; Lacroix, Laetitia; Delfour, Olivier; Vandenberghe, Isabelle; Thuilliez, Céline; Keddani, Sonia; B. Sakhi, Imene; Barret, Éric; Ferré, Pierre; Corvaı̈a, Nathalie; Passioukov, A.; Chetaille, Eric; Botto, Marina; de Reyniès, Aurélien; Oudard, Stéphane; Méjean, Arnaud; Cathelineau, Xavier; Sautès‐Fridman, Catherine; H. Fridman, Wolf

doi:10.1158/2326-6066.cir-18-0891

Public

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

Published in Cancer Immunology Research • Jun 4, 2019

Authors:

Lubka T. Roumenina

Marie V. Daugan

Rémi Noé

Abstract

Abstract Clear-cell renal cell carcinoma (ccRCC) possesses an unmet medical need, particularly at the metastatic stage, when surgery is ineffective. Complement is a key factor in tissue inflammation, favoring cancer progression through the production of complement component 5a (C5a). However, the ac...

Subject

Complement system

Tumor microenvironment

Cancer research

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