Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

Hanseeuw, Bernard; A. Betensky, Rebecca; I.L. Jacobs, Heidi; P. Schultz, Aaron; Sepulcre, Jorge; Alex Becker, J.; M. Cosio, Danielle; E. Farrell, Michelle; T. Quiroz, Yakeel; C. Mormino, Elizabeth; F. Buckley, Rachel; V. Papp, Kathryn; Amariglio, Rebecca; Dewachter, Ilse; Ivanoiu, Adrian; Huijbers, Willem; Hedden, Trey; A. Marshall, Gad; P. Chhatwal, Jasmeer; M. Rentz, Dorene; A. Sperling, Reisa; A. Johnson, Keith

doi:10.1001/jamaneurol.2019.1424

Public

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

Published in JAMA Neurology • Jun 3, 2019

Authors:

Bernard Hanseeuw

Rebecca A. Betensky

Heidi I.L. Jacobs

Abstract

IMPORTANCE: Positron emission tomography (PET) imaging now allows in vivo visualization of both neuropathologic hallmarks of Alzheimer disease (AD): amyloid-β (Aβ) plaques and tau neurofibrillary tangles. Observing their progressive accumulation in the brains of clinically normal older adults is cri...

Subject

Positron emission tomography

Pittsburgh compound B

Cognition

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