Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Charoentong, Pornpimol; Finotello, Francesca; Angelova, Mihaela; Mayer, Clemens; Efremova, Mirjana; Rieder, Dietmar; Hackl, Hubert; Trajanoski, Zlatko

doi:10.1016/j.celrep.2016.12.019

Public

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Published in Cell Reports • Jan 1, 2017

Authors:

Pornpimol Charoentong

Francesca Finotello

Mihaela Angelova

Abstract

The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the majority of patients do not respond to immunotherapy, making the identification of predictive markers and the mechanisms of resis...

Subject

Blockade

Immunophenotyping

Genotype

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