Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Cazet, Aurélie; N. Hui, Mun; Elsworth, Benjamin; Z. Wu, Sunny; Roden, Daniel; Chan, Chia-Ling; N. Skhinas, Joanna; Collot, Raphaël; Yang, Jessica; Harvey, Kate; Zahied Johan, M.; Cooper, Caroline; Nair, Radhika; Herrmann, David; McFarland, Andrea; Deng, Niantao; Ruíz‐Borrego, Manuel; Rojo, Federico; Trigo, José; Bezares, Susana; Caballero, Rosalía; Lim, Elgene; Timpson, Paul; O’Toole, Sandra; Neil Watkins, D.; R. Cox, Thomas; S. Samuel, Michael; Martín, Miguel; Swarbrick, Alexander

doi:10.1038/s41467-018-05220-6

Public

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Published in Nature Communications • Jul 18, 2018

Authors:

Aurélie Cazet

Mun N. Hui

Benjamin Elsworth

Abstract

The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms can...

Subject

Triple-negative breast cancer

Breast cancer

Stromal cell

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