LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors

Arunkumar, Ganesan; Anand, Shankar; Raksha, Partha; Dhamodharan, Shankar; Prasanna Srinivasa Rao, Harikrishnan; Shanmugam, Subbiah; Kannan Murugan, Avaniyapuram; Kannan Munirajan, Arasambattu

doi:10.1038/s41598-018-25451-3

Public

LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors

Published in Scientific Reports • Apr 30, 2018

Authors:

Ganesan Arunkumar

Shankar Anand

Partha Raksha

Abstract

Long non-coding RNAs (lncRNAs) play an important role in the regulation of key cellular processes in early development and cancer. LncRNA Oip5-as1 facilitates stem cell self-renewal in mouse by sponging mmu-miR-7 and modulating NANOG level, yet its role in cancer is less understood. We analyzed OIP5...

Subject

Homeobox protein NANOG

Biology

Downregulation and upregulation

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