Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

Bridel, Claire; N. van Wieringen, Wessel; Zetterberg, Henrik; M. Tijms, Betty; E. Teunissen, Charlotte; the NFL Group, and; C. Álvarez‐Cermeño, José; Andréasson, Ulf; Axelsson, Markus; Bäckström, David; Bartoš, Aleš; Bjerke, Maria; Blennow, Kaj; L. Boxer, Adam; Brundin, Lou; Burman, Joachim; Christensen, Tove; Fialová, L; Forsgren, Lars; Lautrup Frederiksen, Jette; Gisslén, Magnus; Gray, Elizabeth; Gunnarsson, Martin; Hall, Sara; Hansson, Oskar; K. Herbert, Megan; Jakobsson, Joel; Jessen-Krut, Jan; Janelidze, Shorena; Johannsson, Gudmundur; Jonsson, Michael; Kappos, Ludwig; Khademi, Mohsen; Khalil, Michael; Kühle, Jens; Landén, Mikael; Leinonen, Ville; Logroscino, Giancarlo; Lu, Ching‐Hua; Lycke, Jan; Magdalinou, Nadia; Malaspina, Andrea; Mattsson, Niklas; Meeter, Lieke; R. Mehta, Sanjay; Modvig, Signe; Olsson, Tomas; W. Paterson, Ross; Pérez‐Santiago, Josué; Piehl, Fredrik; A.L. Pijnenburg, Yolande; T. Pyykkö, Okko; Ragnarsson, Óskar; C. Rojas, Julio; Romme Christensen, Jeppe; Sandberg, Linda; Scherling, Carole; M. Schott, Jonathan; Sellebjerg, Finn; Laura Simone, Isabella; Skillbäck, Tobias; Stilund, Morten; Sundström, Peter; Svenningsson, Anders; Tortelli, Rosanna; Tortorella, Carla; Trentini, Alessandro; Troiano, Maria; R. Turner, Martin; C. van Swieten, John; Vågberg, Mattias; M. Verbeek, Marcel; María Villar, Luisa; Jelle Visser, Pieter; Wallin, Anders; Weiss, Andreas; Wikkelsø, Carsten; J. Wild, Edward

doi:10.1001/jamaneurol.2019.1534

Public

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

Published in JAMA Neurology • Jun 17, 2019

Authors:

Claire Bridel

Wessel N. van Wieringen

Henrik Zetterberg

Abstract

IMPORTANCE: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disor...

Subject

Cerebrospinal fluid

Medicine

Cohort

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