Sequence Tolerance of a Single-Domain Antibody with
a High Thermal Stability: Comparison of Computational and Experimental
Fitness Profiles

A. Olson, Mark; M. Legler, Patricia; Zabetakis, Daniel; B. Turner, Kendrick; P. Anderson, George; R. Goldman, Ellen

doi:10.1021/acsomega.9b00730

Public

Sequence Tolerance of a Single-Domain Antibody with a High Thermal Stability: Comparison of Computational and Experimental Fitness Profiles

Shared by NobleBlocks on Jun 17, 2019 • 12:00 AM UTC

Authors:

Mark A. Olson

Patricia M. Legler

Daniel Zabetakis

Abstract

Abstract The sequence fitness of a llama single-domain antibody with an unusually high thermal stability is explored by a combined computational and experimental study. Starting with the X-ray crystallographic structure, RosettaBackrub simulations were applied to model sequence–structure tolerance p...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!