A Direct Intramolecular C−H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-<i>a</i>]benzimidazoles from<i>N</i>-Aryl-2-aminopyridines

Wang, Honggen; Wang, Yong; Peng, Changlan; Zhang, Jiancun; Zhu, Qiang

doi:10.1021/ja1067993

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A Direct Intramolecular C−H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles fromN-Aryl-2-aminopyridines

Published in Journal of the American Chemical Society • Sep 7, 2010

Authors:

Honggen Wang

Yong Wang

Changlan Peng

Abstract

A novel and efficient synthesis of pyrido[1,2-a]benzimidazoles through direct intramolecular aromatic C-H amination of N-aryl-2-aminopyridines has been developed. The reaction, cocatalyzed by Cu(OAc)(2) and Fe(NO(3))(3)·9H(2)O, is carried out in DMF under a dioxygen atmosphere. Diversified pyrido[1,...

Subject

Chemistry

Amination

Intramolecular force

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