Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Elyada, Ela; Bolisetty, Mohan; Laise, Pasquale; F. Flynn, William; T. Courtois, Elise; A. Burkhart, Richard; A. Teinor, Jonathan; Belleau, Pascal; Biffi, Giulia; S. Lucito, Matthew; Sivajothi, Santhosh; D. Armstrong, Todd; D. Engle, Dannielle; H. Yu, Kenneth; Yuan, Hao; L. Wolfgang, Christopher; Park, Youngkyu; Preall, Jonathan; M. Jaffee, Elizabeth; Califano, Andrea; Robson, Paul; A. Tuveson, David

doi:10.1158/2159-8290.cd-19-0094

Public

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Published in Cancer Discovery • Jun 13, 2019

Authors:

Ela Elyada

Mohan Bolisetty

Pasquale Laise

Abstract

Abstract Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefin...

Subject

Biology

Tumor microenvironment

Cancer-Associated Fibroblasts

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