Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Dominguez–Valentin, Mev; R. Sampson, Julian; T. Seppälä, Toni; W. ten Broeke, Sanne; Plazzer, John‐Paul; Nakken, Sigve; Engel, Christoph; Aretz, Stefan; A. Jenkins, Mark; Sunde, Lone; Bernstein, Inge; Capellá, Gabriel; Balaguer, Francesc; Thomas, Huw; Gareth Evans, D.; Burn, John; S. Greenblatt, Marc; Hovig, Eivind; H. de Vos tot Nederveen Cappel, Wouter; H. Sijmons, Rolf; Bertario, Lucio; Grazia Tibiletti, Maria; Martina Cavestro, Giulia; Lindblom, Annika; Della Valle, Adriana; López‐Köstner, Francisco; Gluck, Nathan; H. Katz, Lior; Heinimann, Karl; Vaccaro, Carlos; Büttner, Reinhard; Görgens, Heike; Holinski‐Feder, Elke; Morak, Monika; Holzapfel, Stefanie; Hüneburg, Robert; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; K. Schackert, Hans; Steinke‐Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Pylvänäinen, Kirsi; Renkonen‐Sinisalo, Laura; L. Hopper, John; Ko Win, Aung; W. Haile, Robert; M. Lindor, Noralane; Gallinger, Steven; Le Marchand, Loı̈c; A. Newcomb, Polly; C. Figueiredo, Jane; N. Thibodeau, Stephen; Wadt, Karin; Therkildsen, Christina; Okkels, Henrik; Ketabi, Zohreh; Moreira, Leticia; Sánchez, Ariadna; Serra‐Burriel, Miquel; Pineda, Marta; Navarro, Matilde; Blanco, Ignacio; Green, Kate; Lalloo, Fiona; J. Crosbie, Emma; Hill, James; G. Denton, Oliver; M. Frayling, Ian; Andreas Rødland, Einar; F. A. Vasen, Hans; Mints, Miriam; Neffa, Florencia; Esperón, Patricia; Álvarez, Karin; Kariv, Revital; Rosner, Guy; Alejandra Piñero, Tamara; Laura González, María; Kalfayan, Pablo; Tjandra, Douglas; Winship, Ingrid; Macrae, Finlay; Möslein, Gabriela; Mecklin, Jukka‐Pekka; Nielsen, Maartje; Møller, Pål

doi:10.1038/s41436-019-0596-9

Public

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Published in Genetics in Medicine • Jul 23, 2019

Authors:

Mev Dominguez–Valentin

Julian R. Sampson

Toni T. Seppälä

Abstract

PURPOSE: Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome and result in different but imprecisely known cancer risks. This study aimed to provide age and organ-specific cancer risks according to gene and gender and to determine survival after cancer. METHODS: We conducte...

Subject

Cancer

Medicine

Lynch syndrome

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