Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

P. Menden, Michael; Wang, Dennis; J. Mason, Mike; Szalai, Bence; C. Bulusu, Krishna; Guan, Yuanfang; Yu, Thomas; Kang, Jaewoo; Jeon, Minji; Wolfinger, Russ; Nguyen, Tin; Zaslavskiy, Mikhail; Abante, Jordi; Schmitz Abecassis, Barbara; Aben, Nanne; Aghamirzaie, Delasa; Aittokallio, Tero; S. Akhtari, Farida; Al‐Lazikani, Bissan; Alam, Tanvir; Allam, Amin; H. G. Allen, Chad; Pelicano de Almeida, Mariana; Altarawy, Doaa; M. Alves, Vinícius; Amadoz, Alicia; Anchang, Benedict; A. Antolín, Albert; R. Ash, Jeremy; Aznar, V.; Ba-Alawi, Wail; Bagheri, Moeen; B. Bajić, Vladimir; C. Ball, G.; J. Ballester, Pedro; Baptista, Delora; Bare, Christopher; Bateson, Mathilde; Bender, Andreas; Bertrand, Denis; K. Wijayawardena, Bhagya; A. Boroevich, Keith; Bosdriesz, Evert; Bougouffa, Salim; Bounova, Gergana; Brouwer, Thomas; M. Bryant, Barbara; Calaza, Manuel; Calderone, Alberto; Calza, Stefano; J. Capuzzi, Stephen; Carbonell‐Caballero, José; Carlin, Daniel; Carter, Hannah; Castagnoli, Luisa; Çelebi, Remzi; Cesareni, Gianni; Chang, Hyeokyoon; Chen, Guocai; Chen, Hao; Chen, Huiyuan; Cheng, Lijun; Chernomoretz, Ariel; Chicco, Davide; Cho, Kwang‐Hyun; Cho, Sung‐Hwan; Choi, Daeseon; Choi, Jaejoon; Choi, Kwanghun; Choi, Minsoo; De Cock, Martine; A. Coker, Elizabeth; Cortés‐Ciriano, Isidro; Cserző, Miklós; Çubuk, Cankut; Curtis, Christina; Van Daele, Dries; Cao Dang, Cuong; M. H. Dijkstra, Tjeerd; Dopazo, Joaquı́n; Drăghici, Sorin; Drosou, Anastasios; Dumontier, Michel; Ehrhart, Friederike; Eid, Fatma-Elzahraa; ElHefnawi, Mahmoud; Elmarakeby, Haitham; van Engelen, Bo; Billur Engin, H.; J. P. de Esch, Iwan; T. Evelo, Chris; O. Falcão, André; S. Farag, Sherif; Fernandez-Lozano, Carlos; M. Fisch, Kathleen; Flobak, Åsmund; Fornari, Chiara; Foroushani, Amir; Chedom Fotso, Donatien; Fourches, Denis; Friend, Stephen; Frigessi, Arnoldo; Gao, Feng; Gao, Xiaoting; M. Gerold, Jeffrey; Gestraud, Pierre; Ghosh, Samik; Gillberg, Jussi; Godoy‐Lorite, Antonia; Godynyuk, Lizzy; Godzik, Adam; Goldenberg, Anna; Gómez-Cabrero, David; Gönen, Mehmet; de Graaf, Chris; Gray, Harry; Grechkin, Maxim; Guimerà, Roger; Güney, Emre; Haibe‐Kains, Benjamin; Han, Young-Hyun; Hase, Takeshi; He, Di; He, Liye; S. Heath, Lenwood; H. Hellton, Kristoffer; Helmer‐Citterich, Manuela; R. Hidalgo, Marta; Hidru, Daniel; M. Hill, Steven; Hochreiter, Sepp; Hong, Seungpyo; Hovig, Eivind; Hsueh, Ya-Chih; Hu, Zhiyuan; K. Huang, Justin; Stephanie Huang, R.; Hunyady, László; Hwang, Jinseub; Hyun Hwang, Tae; Hwang, Woochang; Hwang, Yongdeuk; Isayev, Olexandr; Bear Don’t Walk, Oliver; Jack, John; Jahandideh, Samad; Ji, Jiadong; Jo, Yousang; J. Kamola, Piotr; K. Kanev, Georgi; Georgiou Karacosta, Loukia; Karimi, Mostafa; Kaski, Samuel; D. Kazanov, Marat; M. Khamis, Abdullah; A. Khan, Suleiman; A. Kiani, Narsis; Kim, Allen; Kim, Jin-Han; Kim, Juntae; Kim, Kiseong; Kim, Kyung‐Hee; Kim, Sunkyu; Kim, Yongsoo; Kim, Yunseong; Kirk, Paul; Kitano, Hiroaki; Klambauer, Günter; A. Knowles, David; E. Ko, Melissa; Köhn‐Luque, Alvaro; J. Kooistra, Albert; A. Kuenemann, Mélaine; Kuiper, Martin; Kurz, Christoph; Kwon, Mijin; van Laarhoven, Twan; Lægreid, Astrid; Lederer, Simone; Lee, Heewon; Lee, Jeon; Woo Lee, Yun; Lepp aho, Eemeli; A. Lewis, Richard; Li, Jing; Li, Lang; Liley, James; Khong Lim, Weng; Hubert Lin, Chieh; Liu, Yiyi; López, Yosvany; Low, Joshua; Lysenko, Artem; Machado, Daniel; S. Madhukar, Neel; De Maeyer, Dries; Belén Malpartida, Ana; Mamitsuka, Hiroshi; Marabita, Francesco; Marchal, Kathleen; Marttinen, Pekka; J. Mason, Daniel; Mazaheri, Alireza; Mehmood, Arfa; Mehreen, Ali; Michaut, Magali; A. Miller, Ryan; Mitsopoulos, Costas; Módos, Dezső; Van Moerbeke, Marijke; Moo, Keagan; A. Motsinger‐Reif, Alison; Movva, Rajiv; Muraru, Sebastian; Muratov, Eugene; Mushthofa, Mushthofa; Nagarajan, Niranjan; Nakken, Sigve; Nath, Aritro; Neuvial, Pierre; Newton, Richard; Zheng, Ning; De Niz, Carlos; Oliva, Baldo; Olsen, Catharina; Palmeri, Antonio; Panesar, Bhawan; Papadopoulos, Stavros; Park, Jaesub; Park, Seonyeong; Park, Sung‐Joon; Pawitan, Yudi; Peluso, Daniele; Pendyala, Sriram; Peng, Jian; Perfetto, Livia; Pirro, S; K. Plevritis, Sylvia; Politi, Regina; Poon, Hoifung; Porta‐Pardo, Eduard; Prellner, Isak; Preuer, Kristina; Ángel Pujana, Miguel; Ramnarine, Ricardo; E. Reid, John; Reyal, Fabien; Richardson, Sylvia; Ricketts, Camir; Rieswijk, Linda; Rocha, Miguel; Rodríguez‐Gonzálvez, Carmen; R. Roell, Kyle; M. Rotroff, Daniel; R. de Ruiter, Julian; Rukawa, Ploy; Sadacca, Benjamin; Safikhani, Zhaleh; Safitri, Fita; Sales‐Pardo, Marta; Sauer, Sebastian; Schlichting, Moritz; A. Seoane, José; Serra, Jordi; Shang, Ming-Mei; Sharma, Alok; M. Sharma, Hari; Shen, Yang; Shiga, M.; Shin, Moonshik; Shkedy, Ziv; E. Shopsowitz, Kevin; Sinai, Sam; Skola, Dylan; Smirnov, Petr; Fourie Soerensen, Izel; Borgen Soerensen, Peter; Song, Je-Hoon; Ok Song, Sang; Soufan, Othman; Spitzmueller, Andreas; Steipe, Boris; Suphavilai, Chayaporn; Pulido Tamayo, Sergio; Tamborero, David; Tang, Jing; Tanoli, Ziaurrehman; Tarrés-Deulofeu, Marc; Tegnér, Jesper; Thommesen, Liv; Ali Madani Tonekaboni, Seyed; Tran, Hong; De Troyer, Ewoud; Truong, Amy; Tsunoda, Tatsuhiko; Turu, Gábor; Tzeng, Guang-Yo; Verbeke, Lieven; Videla, Santiago; J. Vis, Daniël; Voronkov, Andrey; Votis, Konstantinos; Wang, Ashley; Horace Wang, Hong-Qiang; Wang, Po-Wei; Wang, Sheng; Wang, Wei; Wang, Xiaochen; Wang, Xin; Wennerberg, Krister; Wernisch, Lorenz; F.A. Wessels, Lodewyk; J. P. van Westen, Gerard; A. Westerman, Bart; R. White, Simon; Willighagen, Egon; Würdinger, Tom; Xie, Lei; Xie, Shuilian; Xu, Hua; Yadav, Bhagwan; Yau, Christopher; Yeerna, Huwate; Wei Yin, Jia; Yu, Michael; Yu, MinHwan; Jeong Yun, So; Zakharov, Alexey; Zamichos, Alexandros; Zanin, Massimiliano; Zeng, Li; Zenil, Héctor; Zhang, Frederick; Zhang, Pengyue; Zhang, Wei; Zhao, Hongyu; Zhao, Lan; Jim Zheng, W.; Zoufir, Azedine; Zucknick, Manuela; Sock Jang, In; Ghazoui, Zara; Eren Ahsen, Mehmet; Vogel, Robert; Chaibub Neto, Elias; Norman, Thea; Tang, Eric; J. Garnett, Mathew; Y. Di Veroli, Giovanni; E. Fawell, Stephen; Stolovitzky, Gustavo; Guinney, Justin; R. Dry, Jonathan; Sáez-Rodríguez, Julio

doi:10.1038/s41467-019-09799-2

Public

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Published in Nature Communications • Jun 17, 2019

Authors:

Michael P. Menden

Dennis Wang

Mike J. Mason

Abstract

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report As...

Subject

Pharmacogenomics

Drug

Computational biology

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