PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes

R. Aroda, Vanita; Rosenstock, Julio; Terauchi, Yasuo; Altuntaş, Yüksel; M. Lalic, Nebojsa; C. Morales Villegas, Enrique; Kleist Jeppesen, Ole; Christiansen, Erik; L. HERTZ, CHRISTIN; Haluzı́k, Martin; 1 Investigators, PIONEER; Belkacem, Krim; Chiali, Nabil; Bourezane, Samia; Guermaz, R.; Popivanov, P; Lefterov, Ivaylo; Tankova, Tsvetalina; Penchev, I; Košková, Martina; Hudcova, Miroslava; Vesela, Alica; Rancova, Anna; Haluzı́k, Martin; Kiyosue, Arihiro; Matsuoka, Osamu; Inoue, Satoshi; Terauchi, Yasuo; Fukushima, Yasushi; Ide, Yumiko; Ortiz, R.; Villegas, Enrique; Golovach, Albina; Alpenidze, Diana; Frolova, Elena; Zhdanova, Elena; Ruyatkina, Ludmila; Б. Ершова, О.; Г. Самойлова, Ю.; T. Zyangirova, S.; Lalić, Katarina; Lalić, Nebojša; Beljić Živković, Teodora; Esra Ataoğlu, Hayriye; Bakıner, Okan; D. Dayan, A.; Sargın, Mehmet; Mert, Meral; Adaş, Mine; Tabak, Ömür; Altuntaş, Yüksel; V. Murray, Alexander; Iranmanesh, Ali; Schlau, Aron; Wieskopf, Bram; D. Snyder, Brian; J. Griffin, Carl; Fogarty, Charles; Lovell, Charles; Allison, Dale; Fitzpatrick, David; Grant, David; C. Klonoff, David; Williams, Dwayne; Armas, Eddie; M. Palace, Eileen; Ruoff, Gary; Martinez, Gilbert; Perez, Gilberto; Bays, Harold; Tatu, Horia; Maynard, James; Cedeno, Jeanne-Elyse; R. Aroda, Vanita; Park, Jean; Sutton, Jennefer; Pouzar, Joe; Bertsch, John; Condit, Jonathan; Serje, Jorge; Cabaccan, Josel; Risser, Joseph; P. Frías, Juan; Rosenstock, Julio; Sivalingam, Kanagaratnam; Maw, Kelli; Hanson, Lenita; K. Billings, Liana; Connery, Lisa; Juarez, Mario; Lillestol, Michael; Fraser, Neil; Beckett, Paul; Wade, Ralph; Gaona, Raul; F. W. Jackson, Richard; DeLuca, Robert; Alpizar, Sady; J. Herring, Sharon; Stringam, Stanley; M. Bauer, Steven; Gangi, Sumana; Sligh, Teresa; Jarrett, Wentworth; Fitzgibbons, William

doi:10.2337/dc19-0749

Public

PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes

Published in Diabetes Care • Jun 11, 2019

Authors:

Vanita R. Aroda

Julio Rosenstock

Yasuo Terauchi

Abstract

OBJECTIVE This trial compared the efficacy and safety of the first oral glucagon-like peptide 1 (GLP-1) receptor agonist, oral semaglutide, as monotherapy with placebo in patients with type 2 diabetes managed by diet and exercise alone. Two estimands addressed two efficacy-related questions: a treat...

Subject

Semaglutide

Medicine

Placebo

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!