Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

I. Ariöz, Burak; Tastan, Bora; Tarakcioglu, Emre; Uğur Tüfekçi, Kemal; Olcum, Melis; Ersoy, Nevin; Bağrıyanık, Alper; Genç, Kürşad; Genç, Şermin

doi:10.3389/fimmu.2019.01511

Public

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

Published in Frontiers in Immunology • Jul 2, 2019

Authors:

Burak I. Ariöz

Bora Tastan

Emre Tarakcioglu

Abstract

Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is characterized by decreased mobility and depressive behavior that occurs in systemic infection induced by Lipopolysacchari...

Subject

Melatonin

Inflammasome

Microglia

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