SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation

Jiang, Tian-Xia; Zou, Jiang-Bo; Zhu, Qianqian; Hua Liu, Cui; Wang, Guangfei; Du, Tingting; Luo, Zi-Yu; Guo, Fang; Zhou, Luming; Liu, Juanjuan; Zhang, Wensheng; Shu, Yousheng; Yu, Li; Li, Peng; A. Ronai, Ze’ev; Matsuzawa, Shu‐ichi; L. Goldberg, Alfred; Qiu, Xiao‐Bo

doi:10.1073/pnas.1901039116

Public

SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation

Published in Proceedings of the National Academy of Sciences • Jun 18, 2019

Authors:

Tian-Xia Jiang

Jiang-Bo Zou

Qianqian Zhu

Abstract

BRUCE/Apollon is a membrane-associated inhibitor of apoptosis protein that is essential for viability and has ubiquitin-conjugating activity. On initiation of apoptosis, the ubiquitin ligase Nrdp1/RNF41 promotes proteasomal degradation of BRUCE. Here we demonstrate that BRUCE together with the prote...

Subject

Autophagy

Ubiquitin ligase

Cell biology

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