Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Deng, Junli; Bai, Xupeng; Feng, Xiaojie; Ni, Jie; Beretov, Julia; Graham, Peter; Li, Yong

doi:10.1186/s12885-019-5824-9

Public

Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Published in BMC Cancer • Jun 24, 2019

Authors:

Junli Deng

Xupeng Bai

Xiaojie Feng

Abstract

BACKGROUND: Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian cancer (EOC) chemoresistance is not completely uncovered. The phosphatidylinos...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

Cancer research

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