Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Palhano-Fontes, Fernanda; Barreto, Dayanna; Onias, Heloisa; C. Andrade, Kátia; Menezes Novaes, Morgana; Andrade Pessoa, Jéssica; Mota‐Rolim, Sérgio; de Lima Osório, Flávia; Faria Sanches, Rafael; G. dos Santos, Rafael; Fernando Tófoli, Luís; de Oliveira Silveira, Gabriela; Yonamine, Maurı́cio; Riba, Jordi; R. Santos, Francisco; A Silva-Junior, Antonio; Carlos Alchieri, João; Leite Galvão‐Coelho, Nicole; Lobão‐Soares, Bruno; E. C. Hallak, Jaime; Arcoverde, Emerson; Paulo Maia‐de‐Oliveira, João; Barros de Araújo, Dráulio

doi:10.1017/s0033291718001356

Public

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Published in Psychological Medicine • Jun 15, 2018

Authors:

Fernanda Palhano-Fontes

Dayanna Barreto

Heloisa Onias

Abstract

BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 ...

Subject

Ayahuasca

Placebo

Depression (economics)

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