The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of <i>CYR61</i> mRNA

Li, Xiaocui; Jin, Feng; Wang, Bei-Ying; Yin, Xiang-Jie; Hong, Wei; Tian, Fu‐Ju

doi:10.7150/thno.31868

Public

The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA

Published in Theranostics • Jan 1, 2019

Authors:

Xiaocui Li

Feng Jin

Bei-Ying Wang

Abstract

N 6 -Methyladenosine (m 6 A) is the most prevalent internal modification in mammalian mRNAs. Although m 6 A is important in many biological processes, its roles in the placenta are unclear. Methods: Levels of global mRNA m 6 A methylation and ALKBH5 expression in recurrent miscarriage (RM) patients ...

Subject

Trophoblast

Gene knockdown

Biology

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