Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

R. Wilson, Michael; A. Sample, Hannah; C. Zorn, Kelsey; Arevalo, Shaun; Yu, Guixia; Neuhaus, John; Federman, Scot; Stryke, Doug; Briggs, Benjamin; Langelier, Charles; Berger, Amy; C. Douglas, Vanja; Andrew Josephson, S.; C. Chow, Felicia; D. Fulton, Brent; L. DeRisi, Joseph; M. Gelfand, Jeffrey; N. Naccache, Samia; M. Bender, Jeffrey; Dien Bard, Jennifer; A. Murkey, Jamie; Carlson, Magrit; Vespa, Paul; Vijayan, Tara; R Allyn, Paul; Campeau, Shelley; M. Humphries, Romney; D. Klausner, Jeffrey; D. Ganzon, Czarina; Memar, Fatemeh; A. Ocampo, Nicolle; Zimmermann, Lara; H. Cohen, Stuart; R. Polage, Christopher; L. DeBiasi, Roberta; Haller, Barbara; H. Dallas, Ronald; Marón, Gabriela; T. Hayden, Randall; Messacar, Kevin; R. Dominguez, Samuel; Miller, Steve; Y. Chiu, Charles

doi:10.1056/nejmoa1803396

Public

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

Published in New England Journal of Medicine • Jun 12, 2019

Authors:

Michael R. Wilson

Hannah A. Sample

Kelsey C. Zorn

Abstract

BACKGROUND: Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potential to identify a broad range of pathogens in a single test. METHODS: In a 1-year, multicenter, prospective study, we investigated the usefulness of metagenomic NGS of CSF for the diagnosis of infecti...

Subject

Metagenomics

Medicine

Encephalitis

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