Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy

C. Fervenza, Fernando; B. Appel, Gerald; J. Barbour, Sean; H. Rovin, Brad; Lafayette, Richard; Aslam, Nabeel; Ashley Jefferson, Jonathan; E. Gipson, Patrick; V. Rizk, Dana; R. Sedor, John; F. Simon, James; T. McCarthy, Ellen; Brenchley, Paul; Sethi, Sanjeev; Ávila-Casado, Carmen; Beanlands, Heather; C. Lieske, John; Philibert, David; Li, Tingting; F. Thomas, Leslie; F. Green, Dolly; A. Juncos, Luis; Beara‐Lasić, Lada; S. Blumenthal, Samuel; N. Sussman, Amy; B. Erickson, Stephen; Hladunewich, Michelle; A. Canetta, Pietro; A. Hebert, Lee; Leung, Nelson; Radhakrishnan, Jay; N. Reich, Heather; V. Parikh, Samir; S. Gipson, Debbie; K. Lee, Dominic; R. da Costa, Bruno; Jüni, Peter; Cattran, Daniel

doi:10.1056/nejmoa1814427

Public

Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy

Published in New England Journal of Medicine • Jul 3, 2019

Authors:

Fernando C. Fervenza

Gerald B. Appel

Sean J. Barbour

Abstract

BACKGROUND: B-cell anomalies play a role in the pathogenesis of membranous nephropathy. B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for inducing and maintaining a complete or partial remission of proteinuria in patients with this condition. METHODS: of...

Subject

Rituximab

Membranous nephropathy

Medicine

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