Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

Saito, Takashi; Mihira, Naomi; Matsuba, Yukio; Sasaguri, Hiroki; Hashimoto, Shoko; Narasimhan, Sneha; Zhang, Bin; Murayama, Shigeo; Higuchi, Makoto; M.‐Y. Lee, Virginia; Q. Trojanowski, John; C. Saido, Takaomi

doi:10.1074/jbc.ra119.009487

Public

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

Published in Journal of Biological Chemistry • Jul 5, 2019

Authors:

Takashi Saito

Naomi Mihira

Yukio Matsuba

Abstract

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD), extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological intracellular tau (the product of the gene microtubule-associated protein tau (MAPT)). To our knowledge, current mous...

Subject

Tauopathy

Gene knockin

Tau protein

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