Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Olivieri, Pauline; Lagarde, Julien; Lehéricy, Stéphane; Valabrègue, Romain; Michel, Adeline; Mace, Pierre; Caillé, Fabien; Gervais, Philippe; Bottlaender, Michel; Sarazin, Marie

doi:10.1002/acn3.50818

Public

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Published in Annals of Clinical and Translational Neurology • Jun 23, 2019

Authors:

Pauline Olivieri

Julien Lagarde

Stéphane Lehéricy

Abstract

Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC-I) on 3T MRI to assess the LC integrity in AD (n = 37) and controls (n = 17). The LC-I was decreased in AD regardless of typical (amnes...

Subject

Locus coeruleus

Tauopathy

Medicine

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