Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.

Santis R, De; V, Alfano; Turris V, de; A, Colantoni; L, Santini; MG, Garone; G, Antonacci; G, Peruzzi; E, Sudria-Lopez; E, Wyler; JJ, Anink; E, Aronica; M, Landthaler; RJ, Pasterkamp; I, Bozzoni; A, Rosa

doi:10.1016/j.celrep.2019.05.085

Public

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.

Shared by NobleBlocks on Jun 1, 2019 • 12:00 AM UTC

Authors:

De Santis R

Alfano V

de Turris V

Abstract

Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets. Whereas the wild-type protein pr...

Subject

RNA-binding protein

Motor neuron

Fus

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