Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

R. Masson, Glenn; E. Burke, John; G. Ahn, Natalie; S. Anand, Ganesh; H. Borchers, Christoph; Brier, Sébastien; M. Bou-Assaf, George; R. Engen, John; Walter Englander, S.; H. Faber, Johan; A. Garlish, Rachel; R. Griffin, Patrick; L. Gross, Michael; Guttman, Miklós; Hamuro, Yoshitomo; J. R. Heck, Albert; J. Houde, Damian; E. Iacob, Roxana; J. D. Jørgensen, Thomas; A. Kaltashov, Igor; P. Klinman, Judith; Konermann, Lars; Man, Petr; Mayne, Leland; D. Pascal, Bruce; Reichmann, Dana; Skehel, Mark; Snijder, Joost; S. Strutzenberg, Timothy; S. Underbakke, Eric; Wagner, Cornelia; E. Wales, Thomas; T. Walters, Benjamin; D. Weis, David; J. Wilson, Derek; L. Wintrode, Patrick; Zhang, Zhongqi; Zheng, Jie; C. Schriemer, David; D. Rand, Kasper

doi:10.1038/s41592-019-0459-y

Public

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Published in Nature Methods • Jun 27, 2019

Authors:

Glenn R. Masson

John E. Burke

Natalie G. Ahn

Abstract

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhanc...

Subject

Hydrogen–deuterium exchange

Mass spectrometry

Deuterium

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