Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non–Small Cell Lung Cancer

S.M.E. Theelen, Willemijn; Peulen, Heike; Lalezari, Ferry; van der Noort, Vincent; F. de Vries, Jeltje; G.J.V. Aerts, Joachim; W. Dumoulin, Daphne; Bahce, Idris; N. Niemeijer, Anna-Larissa; J. de Langen, Adrianus; Monkhorst, Kim; Baas, Paul

doi:10.1001/jamaoncol.2019.1478

Public

Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non–Small Cell Lung Cancer

Published in JAMA Oncology • Jul 11, 2019

Authors:

Willemijn S.M.E. Theelen

Heike Peulen

Ferry Lalezari

Abstract

IMPORTANCE: Many patients with advanced non-small cell lung cancer (NSCLC) receiving immunotherapy show primary resistance. High-dose radiotherapy can lead to increased tumor antigen release, improved antigen presentation, and T-cell infiltration. This radiotherapy may enhance the effects of checkpo...

Subject

Medicine

Pembrolizumab

Oncology

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