Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial

Castro, Mario; Sperb Rubin, Adalberto; Laviolette, Michel; Fiterman, Jussara; De Andrade Lima, Marina; L. Shah, Pallav; Fiss, Elie; Olivenstein, Ronald; C. Thomson, Neil; Niven, Robert; Pavord, Ian; Simoff, Michael; Duhamel, David; McEvoy, Charlene; G. Barbers, Richard; ten Hacken, N.H.T.; E. Wechsler, Michael; Holmes, Mark; J. Phillips, Martin; C. Erzurum, Serpil; Lunn, William; Israel, Elliot; N. Jarjour, Nizar; Kraft, Monica; S. Shargill, Narinder; Quiring, John; Berry, Scott; Cox, Gerard

doi:10.1164/rccm.200903-0354oc

Public

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial

Published in American Journal of Respiratory and Critical Care Medicine • Oct 8, 2009

Authors:

Mario Castro

Adalberto Sperb Rubin

Michel Laviolette

Abstract

RATIONALE: Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle. OBJECTIVES: To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic des...

Subject

Medicine

Bronchial thermoplasty

Clinical endpoint

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