Biogenesis of lysosome‐related organelles complex‐1 (BORC) regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate

E. Yordanov, Teodor; E. B. Hipolito, Victoria; Liebscher, Gudrun; F. Vogel, Georg; Stasyk, Taras; Herrmann, Caroline; Geley, Stephan; Teis, David; J. Botelho, Roberto; W. Hess, Michael; A. Huber, Lukas

doi:10.1111/tra.12679

Public

Biogenesis of lysosome‐related organelles complex‐1 (BORC) regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate

Published in Traffic • Jul 17, 2019

Authors:

Teodor E. Yordanov

Victoria E. B. Hipolito

Gudrun Liebscher

Abstract

Abstract Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal multimeric BLOC‐1‐related complex (BORC) reg...

Subject

Cell biology

Endosome

Lysosome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!