Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.

S, Chothani; S, Schäfer; E, Adami; S, Viswanathan; AA, Widjaja; SR, Langley; J, Tan; M, Wang; NM, Quaife; Pua C, Jian; G, D'Agostino; Shekeran S, Guna; BL, George; S, Lim; Cao E, Yiqun; Heesch S, van; F, Witte; LE, Felkin; EG, Christodoulou; J, Dong; S, Blachut; G, Patone; PJR, Barton; N, Hubner; SA, Cook; OJL, Rackham

doi:10.1161/circulationaha.119.039596

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Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.

Shared by NobleBlocks on Jul 9, 2019 • 12:00 AM UTC

Authors:

Chothani S

Schäfer S

Adami E

Abstract

Background Fibrosis is a common pathology in many cardiac disorders and is driven by the activation of resident fibroblasts. The global posttranscriptional mechanisms underlying fibroblast-to-myofibroblast conversion in the heart have not been explored.Methods Genome-wide changes of RNA transcriptio...

Subject

Dilated cardiomyopathy

TGF-beta1

RNA-binding proteins

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