Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

A. Martinello, Kathryn; Meehan, Christopher; Avdic-Belltheus, Adnan; Lingam, Ingran; Ragab, Sara; Hristova, Mariya; J Tann, Cally; Peebles, Donald; Hagberg, Henrik; G. A. M. Wolfs, Tim; Klein, Nigel; Tachtsidis, Ilias; Golay, Xavier; W. Kramer, Boris; Fleiss, Bobbi; Gressèns, Pierre; J. Robertson, Nicola

doi:10.1038/s41598-019-46488-y

Public

Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Published in Scientific Reports • Jul 15, 2019

Authors:

Kathryn A. Martinello

Christopher Meehan

Adnan Avdic-Belltheus

Abstract

Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain c...

Subject

Sensitization

Encephalopathy

Medicine

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