Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Liu, Hao; Song, Ying; Qiu, Huishi; Liu, Yanzhen; Luo, Kai; Yi, Yanmei; Jiang, Guanmin; Lu, Minying; Zhang, Zhijie; Yin, Jiang; Zeng, Shanshan; Chen, Xiangzhou; Deng, Min; Jia, Xiaoting; Gu, Yixue; Chen, Danyang; Zheng, Guopei; He, Zhimin

doi:10.1038/s41418-019-0389-3

Public

Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Published in Cell Death and Differentiation • Jul 11, 2019

Authors:

Hao Liu

Ying Song

Huishi Qiu

Abstract

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for BCSC function is vital for the development of therapies. Here, we report that DNMT1-mediated FOXO3a promoter hypermethy...

Subject

FOXM1

SOX2

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!