Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Pantel, Jacques; J. Watson, Hunna; Yılmaz, Zeynep; M. Thornton, Laura; Hübel, Christopher; R. I. Coleman, Jonathan; A. Gaspar, Héléna; Bryois, Julien; Hinney, Anke; Leppä, Virpi; Mattheisen, Manuel; E. Medland, Sarah; Ripke, Stephan; Yao, Shuyang; Giusti‐Rodríguez, Paola; B. Hanscombe, Ken; L. Purves, Kirstin; A.H. Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; A. Andreassen, Ole; H. Baker, Jessica; H. Berrettini, Wade; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; D. Cone, Roger; Courtet, Philippe; J. Crow, Scott; J. Crowley, James; N. Danner, Unna; S. P. Davis, Oliver; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; E. DeSocio, Janiece; M. Dick, Danielle; Dikeos, Dimitris; Dina, Christian; Dmitrzak‐Węglarz, Monika; Docampo, Elisa; E. Duncan, Laramie; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Esko, Tõnu; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández‐Aranda, Fernando; M. Fichter, Manfred; Fischer, Krista; Föcker, Manuel; Foretová, Lenka; J. Forstner, Andreas; Forzan, Monica; S. Franklin, Christopher; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Gratacos Mayora, Monica; Guillaume, Sébastien; Guo, Yiran; Håkonarson, Håkon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; G. Helder, Sietske; Herms, Stefan; Herpertz‐Dahlmann, Beate; Herzog, Wolfgang; M. Huckins, Laura; I. Hudson, James; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimí­r; Jiménez‐Múrcia, Susana; Julià, Antonio; Kalsi, Gursharan; Kaminská, Deborah; Kaprio, Jaakko; Karhunen, Leila; Karwautz, Andreas; J. Kas, Martien; L. Kennedy, James; Keski‐Rahkonen, Anna; Kiezebrink, Kirsty; Kim, Youl‐Ri; Klareskog, Lars; L. Klump, Kelly; Peggy Knudsen, Gun; C. La Via, Maria; Le Hellard, Stéphanie; D. Levitan, Robert; Li, Dong; Lilenfeld, Lisa; Lin, Bochao; Lissowska, Jolanta; J. Luykx, Jurjen; J. Magistretti, Pierre; Maj, Mario; Männik, Katrin; Marsal, Sara; R. Marshall, Christian; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; S. Mitchell, Karen; Maria Monteleone, Alessio; Monteleone, Palmiero; A. Munn‐Chernoff, Melissa; Nacmias, Benedetta; Navratilova, Marie; Ντάλλα, Ιωάννα; K. O’Toole, Julie; A. Ophoff, Roel; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papežová, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolás; Reichborn‐Kjennerud, Ted; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André; W. Scherer, Stephen; Schmidt, Ulrike; J. Schork, Nicholas; Schosser, Alexandra; Seitz, Jochen; Šlachtová, Lenka; Eline Slagboom, P.; Landt, M; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata; P. Szatkiewicz, Jin; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Τσίτσικα, Άρτεμις; Tyszkiewicz‐Nwafor, Marta; Tziouvas, Konstantinos; Elburg, Annemarie; F. van Furth, Eric; Wagner, Gudrun; Walton, Esther; Widén, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; W. Bergen, Andrew; M. Boden, Joseph; Brandt, Harry; Crawford, Steven; A. Halmi, Katherine; John Horwood, L.; Johnson, Craig; S. Kaplan, Allan; H. Kaye, Walter; E. Mitchell, James; M. Olsen, Catherine; F. Pearson, John; L. Pedersen, Nancy; Strober, Michael; Werge, Thomas; C. Whiteman, David; Blake Woodside, D.; D. Stuber, Garret; D. Gordon, Scott; Grove, Jakob; K. Henders, Anjali; Juréus, Anders; M. Kirk, Katherine; Tidselbak Larsen, Janne; Parker, Richard; Petersen, Liselotte; Jordan, Jennifer; A. Kennedy, Martin; W. Montgomery, Grant; Wade, Tracey; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Landén, Mikael; G. Martin, Nicholas; Bo Mortensen, Preben; F. Sullivan, Patrick; Breen, Gerome; M. Bulik, Cynthia

doi:10.1038/s41588-019-0439-2

Public

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Published in Nature Genetics • Jul 15, 2019

Authors:

Jacques Pantel

Hunna J. Watson

Zeynep Yılmaz

Abstract

and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentati...

Subject

Biology

Anorexia nervosa

Genome-wide association study

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