gH625 Cell-Penetrating Peptide Promotes the Endosomal Escape of Nanovectorized siRNA in a Triple-Negative Breast Cancer Cell Line

Ben Djemaa, S.; Hervé-Aubert, Katel; Lajoie, Laurie; Falanga, Annarita; Galdiero, Stefania; Nédellec, Steven; Soucé, Martin; Munnier, Emilie; Chourpa, Igor; David, Stéphanie; Allard-Vannier, Émilie

doi:10.1021/acs.biomac.9b00637

Public

gH625 Cell-Penetrating Peptide Promotes the Endosomal Escape of Nanovectorized siRNA in a Triple-Negative Breast Cancer Cell Line

Published in Biomacromolecules • Jul 15, 2019

Authors:

S. Ben Djemaa

Katel Hervé-Aubert

Laurie Lajoie

Abstract

The use of small interfering RNA (siRNA) to regulate oncogenes appears as a promising strategy in the context of cancer therapy, especially if they are vectorized by a smart delivery system. In this study, we investigated the cellular trafficking of a siRNA nanovector (called CS-MSN) functionalized ...

Subject

Endosome

Endocytosis

Small interfering RNA

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