Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Helen Antunes, Krist; Luís Fachi, José; de Paula, Rosemeire; Fraga da Silva, Emanuelle; Passariello Pral, Laís; A. Santos, Adara; Brisa Malaquias Dias, Greicy; Eduardo Vargas, José; Puga, Renato; Quoos Mayer, Fabiana; Luiz Dal Moro Maito, Fábio; R. Zárate-Bladés, Carlos; J. Ajami, Nadim; Ramos Sant’Ana, Marcella; Candreva, Thamiris; Gomes Rodrigues, Hosana; Schmiele, Márcio; Teresa Pedrosa Silva Clerici, María; Luiz Proença‐Módena, José; T. Vieira, Angélica; R. Mackay, Charles; Santos Mansur, Daniel; T. Caballero, Mauricio; Marzec, Jacqui; Li, Jianying; Wang, Xuting; A. Bell, Douglas; P. Polack, Fernando; R. Kleeberger, Steven; T. Stein, Renato; Aurélio Ramirez Vinolo, Marco; Paula Duarte de Souza, Ana

doi:10.1038/s41467-019-11152-6

Public

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Published in Nature Communications • Jul 22, 2019

Authors:

Krist Helen Antunes

José Luís Fachi

Rosemeire de Paula

Abstract

Abstract Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration o...

Subject

Interferon

Virology

Respiratory system

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