Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

Xu, Pengfei; Zhang, Xiaohao; Liu, Qian; Xie, Yi; Shi, Xiaolei; Chen, Jingjing; Li, Yunzi; Guo, Hongquan; Sun, Rui; Hong, Ye; Liu, Xinfeng; Xu, Gelin

doi:10.1038/s41419-019-1777-9

Public

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

Published in Cell Death and Disease • Jul 19, 2019

Authors:

Pengfei Xu

Xiaohao Zhang

Qian Liu

Abstract

Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of microglial activation and collateral brain injury contributed by robust inflammatory effects. Triggering receptor expressed on myeloid cells (TREM)-1, an amplifier of the innate immune response, is a criti...

Subject

Syk

Neuroinflammation

Microglia

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