Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

W. van der Pluijm, Rob; Imwong, Mallika; Hoàng Châu, Nguyễn; Thi Hoa, Nhu; Nguyen, Thuy-Nhien; Viet Thanh, Ngo; Jittamala, Podjanee; Hanboonkunupakarn, Borimas; Chutasmit, Kitipumi; Saelow, Chalermpon; Runjarern, Ratchadaporn; Kaewmok, Weerayuth; Tripura, Rupam; J. Peto, Thomas; Sovann, Yok; Suon, Seila; Sreng, Sokunthea; Mao, Sivanna; Oun, Savuth; Yen, Sovannary; Amaratunga, Chanaki; Lek, Dysoley; Huy, Rekol; Dhorda, Mehul; Chotivanich, Kesinee; A. Ashley, Elizabeth; Mukaka, Mavuto; Waithira, Naomi; Yeong Cheah, Phaik; J. Maude, Richard; Amato, Roberto; D. Pearson, Richard; Gonçalves, Sónia; G. Jacob, Christopher; L. Hamilton, William; M. Fairhurst, Rick; Tärning, Joel; Winterberg, Markus; Kwiatkowski, Dominic; Pukrittayakamee, Sasithon; Tinh Hien, Tran; Day, Nicholas; Miotto, Olivo; J. White, Nicholas; M. Dondorp, Arjen

doi:10.1016/s1473-3099(19)30391-3

Public

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

Published in The Lancet Infectious Diseases • Jul 22, 2019

Authors:

Rob W. van der Pluijm

Mallika Imwong

Nguyễn Hoàng Châu

Abstract

BACKGROUND: The emergence and spread of resistance in Plasmodium falciparum malaria to artemisinin combination therapies in the Greater Mekong subregion poses a major threat to malaria control and elimination. The current study is part of a multi-country, open-label, randomised clinical trial (TRACI...

Subject

Piperaquine

Malaria

Plasmodium falciparum

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