Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Porcu, Eleonora; Rüeger, Sina; Lepik, Kaido; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Kumar Andiappan, Anand; Arindrarto, Wibowo; Awadalla, Philip; Battle, Alexis; Beutner, Frank; Jan Bonder, Marc; I. Boomsma, Dorret; Christiansen, Mark; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; M. Frayling, Timothy; A. Gharib, Sina; Gibson, Gregory; T. Heijmans, Bastiaan; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johannes; Kim, Yungil; Kirsten, Holger; Kovács, Péter; Krohn, Knut; Kronberg-Guzman, Jaanika; Kukushkina, Viktorija; Lee, Bernett; Lehtimäki, Terho; Loeffler, Markus; M. Marigorta, Urko; Mei, Hailang; Milani, Lili; W. Montgomery, Grant; Müller‐Nurasyid, Martina; Nauck, Matthias; G. Nivard, Michel; W.J.H. Penninx, Brenda; Perola, Markus; Pervjakova, Natalia; L. Pierce, Brandon; E. Powell, Joseph; Prokisch, Holger; M. Psaty, Bruce; T. Raitakari, Olli; Ripatti, Samuli; Rötzschke, Olaf; Saha, Ashis; Scholz, Markus; Schramm, Katharina; Seppälä, Ilkka; Eline Slagboom, P.; D.A. Stehouwer, Coen; Stümvoll, Michael; Sullivan, Patrick; A.C. ’t Hoen, Peter; Teumer, Alexander; Thiery, Joachim; Lin, Tong; Tönjes, Anke; van Dongen, Jenny; van Iterson, Maarten; B. J. van Meurs, Joyce; H. Veldink, Jan; Verlouw, Joost; M. Visscher, Peter; Völker, Uwe; Võsa, Urmo; Westra, Harm-Jan; Wijmenga, Cisca; Yaghootkar, Hanieh; Yang, Jian; Zeng, Biao; Zhang, Futao; Arindrarto, Wibowo; Beekman, Marian; I. Boomsma, Dorret; Bot, Jan; Deelen, Joris; Deelen, Patrick; Franke, Lude; T. Heijmans, Bastiaan; A.C. ’t Hoen, Peter; A. Hofman, Bert; J. Hottenga, Jouke; Isaacs, Aaron; Jan Bonder, Marc; Mila Jhamai, P.; Jansen, Rick; M. Kiełbasa, Szymon; Lakenberg, Nico; Luijk, René; Mei, Hailiang; Moed, Matthijs; Nooren, Irene; Pool, René; G. Schalkwijk, Casper; Eline Slagboom, P.; D.A. Stehouwer, Coen; Eka D. Suchiman, H.; A. Swertz, Morris; F. Tigchelaar, Ettje; G. Uitterlinden, André; H. van den Berg, Leonard; van der Breggen, Ruud; Kallen, Carla; van Dijk, Freerk; van Dongen, Jenny; M. van Duijn, Cornelia; van Galen, Michiel; M. J. van Greevenbroek, Marleen; van Heemst, Diana; van Iterson, Maarten; B. J. van Meurs, Joyce; van Rooij, Jeroen; van’t Hof, Peter; W. van Zwet, Erik; Vermaat, Martijn; H. Veldink, Jan; Verbiest, Michaël; Verkerk, Marijn; Wijmenga, Cisca; V. Zhernakova, Dasha; Zhernakova, Sasha; Santoni, Federico; Reymond, Alexandre; Kutalik, Zoltán

doi:10.1038/s41467-019-10936-0

Public

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Published in Nature Communications • Jul 24, 2019

Authors:

Eleonora Porcu

Sina Rüeger

Kaido Lepik

Abstract

Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, ...

Subject

Mendelian randomization

Genome-wide association study

Pleiotropy

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