Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Jiang, Hua; He, Hongbin; Chen, Yun; Huang, Wei; Cheng, Jinbo; Ye, Jin; Wang, Aoli; Tao, Jin‐Hui; Wang, Chao; Liu, Qingsong; Jin, Tengchuan; Jiang, Wei; Deng, Xianming; Zhou, Rongbin

doi:10.1084/jem.20171419

Public

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Published in The Journal of Experimental Medicine • Oct 11, 2017

Authors:

Hua Jiang

Hongbin He

Yun Chen

Abstract

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome activation, but compounds directly and specifically targeting NLRP3 are still not available, so it is unclear whether NLRP3 itself can...

Subject

Inflammasome

In vivo

Pathogenesis

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