Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

Juanola, Oriol; Ferrusquía‐Acosta, José; Garcı́a-Villalba, Rocío; Zapater, Pedro; Magaz, Marta; Marín, Alicia; Olivas, Pol; Baiges, Anna; Bellot, Pablo; Turón, Fanny; Hernández–Gea, Virginia; M. González‐Navajas, José; A. Tómas‐Barberán, Francisco; Carlos García‐Pagán, Juan; Francés, Rubén

doi:10.1096/fj.201901327r

Public

Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

Published in The FASEB Journal • Jul 25, 2019

Authors:

Oriol Juanola

José Ferrusquía‐Acosta

Rocío Garcı́a-Villalba

Abstract

ABSTRACT Short‐chain fatty acids (SCFAs) are gut microbiota‐derived products that participate in maintaining the gut barrier integrity and host's immune response. We hypothesize that reduced SCFA levels are associated with systemic inflammation, endotoxemia, and more severe hemodynamic alterations i...

Subject

Systemic inflammation

Cirrhosis

Medicine

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