IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma

Wu, Jian; Gao, Fengxia; Wang, Chao; Qin, Mei; Han, Fei; Xu, Tao; Hu, Zhi; Long, Yang; He, Xuemei; Deng, Xin; Ren, De-lian; Dai, Tianyang

doi:10.1186/s13046-019-1310-0

Public

IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma

Published in Journal of Experimental & Clinical Cancer Research • Jul 19, 2019

Authors:

Jian Wu

Fengxia Gao

Chao Wang

Abstract

BACKGROUND: Recurrence and metastasis are the leading causes of tumour-related death in patients with oesophageal squamous cell carcinoma (ESCC). Tumour-infiltrating natural killer cells (NK cells) display powerful cytotoxicity to tumour cells and play a pivotal role in tumour therapy. However, the ...

Subject

Cancer research

Flow cytometry

Granzyme B

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