Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

Raghavan, Shreya; Mehta, Pooja; Xie, Yuying; L. Lei, Yu; Mehta, Geeta

doi:10.1186/s40425-019-0666-1

Public

Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

Published in Journal for ImmunoTherapy of Cancer • Jul 19, 2019

Authors:

Shreya Raghavan

Pooja Mehta

Yuying Xie

Abstract

BACKGROUND: Innate immune cells such as macrophages are abundantly present within malignant ascites, where they share the microenvironment with ovarian cancer stem cells (CSC). METHODS: macrophages (derived from U937 or peripheral blood monocytes) make up ~ 20% of the population, while the rest are ...

Subject

Cancer stem cell

Ovarian cancer

Cancer research

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