Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

S. Abdelfattah, Ahmed; Kawashima, Takashi; Singh, Amrita; Novak, Ondrej; Liu, Hui; Shuai, Yichun; Huang, Yi-Chieh; Campagnola, Luke; C. Seeman, Stephanie; Yu, Jianing; Zheng, Jihong; B. Grimm, Jonathan; Patel, Ronak; Friedrich, Johannes; D. Mensh, Brett; Paninski, Liam; J. Macklin, John; J. Murphy, Gabe; Podgorski, Kaspar; Lin, Bei-Jung; Chen, Tsai-Wen; C. Turner, Glenn; Liu, Zhe; Koyama, Minoru; Svoboda, Karel; B. Ahrens, Misha; D. Lavis, Luke; R. Schreiter, Eric

doi:10.1126/science.aav6416

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Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

Shared by NobleBlocks on Aug 16, 2019 • 12:00 AM UTC

Authors:

Ahmed S. Abdelfattah

Takashi Kawashima

Amrita Singh

Abstract

Visualizing neuronal activity in vivo Imaging the changes in fluorescence of voltage-sensitive reagents would enable monitoring of the activity of neurons in vivo. Abdelfattah et al. created such a voltage indicator by designing a protein that combines the voltage sensor domain from microbial rhodop...

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