Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries

Xie, Xiao; Zuffo, Michela; Teulade‐Fichou, Marie‐Paule; Granzhan, Anton

doi:10.3762/bjoc.15.183

Public

Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries

Published in Beilstein Journal of Organic Chemistry • Aug 6, 2019

Authors:

Xiao Xie

Michela Zuffo

Marie‐Paule Teulade‐Fichou

Abstract

A library of 52 distyryl and 9 mono-styryl cationic dyes was synthesized and investigated with respect to their optical properties, propensity to aggregation in aqueous medium, and capacity to serve as fluorescence “light-up” probes for G-quadruplex (G4) DNA and RNA structures. Among the 61 compound...

Subject

Chemistry

Fluorescence

G-quadruplex

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