Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection

Y. James, Timothy; A. Michelotti, Lucas; D. Glasco, Alexander; A. Clemons, Rebecca; A. Powers, Robert; S James, Ellen; Rabern Simmons, D.; Bai, Feng‐Yan; Ge, Shu-Hua

doi:10.1534/genetics.119.302411

Public

Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection

Published in Genetics • Aug 1, 2019

Authors:

Timothy Y. James

Lucas A. Michelotti

Alexander D. Glasco

Abstract

Abstract Loss of heterozygosity (LOH) is observed during vegetative growth and reproduction of diploid genotypes through mitotic crossovers, aneuploidy caused by nondisjunction, and gene conversion. We aimed to test the role that LOH plays during adaptation of two highly heterozygous Saccharomyces c...

Subject

Biology

Loss of heterozygosity

Saccharomyces cerevisiae

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