Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death

El Banna, Nadine; Hatem, Elie; Heneman-Masurel, Amélie; Léger, Thibaut; Baïlle, Dorothée; Vernis, Laurence; Garcia, Camille; Martineau, Sylvain; Dupuy, Corinne; Vagner, Stéphan; Camadro, Jean‐Michel; Huang, Meng‐Er

doi:10.1016/j.redox.2019.101290

Public

Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death

Published in Redox Biology • Aug 2, 2019

Authors:

Nadine El Banna

Elie Hatem

Amélie Heneman-Masurel

Abstract

Vitamin C (VitC) possesses pro-oxidant properties at high pharmacologic concentrations which favor repurposing VitC as an anti-cancer therapeutic agent. However, redox-based anticancer properties of VitC are yet partially understood. We examined the difference between the reduced and oxidized forms ...

Subject

Cytotoxicity

Ascorbic acid

Glutathione

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