Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Christopher Chamcheu, Jean; Roy, Tithi; B. Uddin, Mohammad; Banang‐Mbeumi, Sergette; Chamcheu, Roxane-Cherille; L. Walker, Anthony; Liu, Yu; Huang, Shile

doi:10.3390/cells8080803

Public

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Published in Cells • Jul 31, 2019

Authors:

Jean Christopher Chamcheu

Tithi Roy

Mohammad B. Uddin

Abstract

The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, and survival, as well as angiogenesis and metabolism. Dysregulation of these pathways is frequently associat...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

Cancer research

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!