Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

Tibor Kozma, Gergely; Mészáros, Tamás; Vashegyi, Ildikó; Fülöp, Tamás; Őrfi, Erik; Dézsi, László; Rosivall, László; Bavli, Yaelle; Urbanics, Rudolf; Eirik Mollnes, Tom; Barenholz, Yechezkel; Szebeni, János

doi:10.1021/acsnano.9b03942

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Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

Published in ACS Nano • Jul 26, 2019

Authors:

Gergely Tibor Kozma

Tamás Mészáros

Ildikó Vashegyi

Abstract

the classical pathway, entailing anaphylactoid shock and accelerated blood clearance of liposome-IgM complexes. These data suggest that complement activation plays a causal role in severe HSRs to PEGylated nanomedicines and that pigs can be used as a hazard identification model to assess the risk of...

Subject

Liposome

Complement system

PEG ratio

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