A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, Joris; S. Evans, Daniel; E. Arking, Dan; Tesi, Niccoló; Nygaard, Marianne; Liu, Xiaomin; K. Wojczynski, Mary; L. Biggs, Mary; van der Spek, Ashley; Atzmon, Gil; B. Ware, Erin; Sarnowski, Chloé; V. Smith, Albert; Seppälä, Ilkka; J. Cordell, Heather; Dose, Janina; Amin, Najaf; M. Arnold, Alice; L. Ayers, Kristin; Barzilai, Nir; J. Becker, Elizabeth; Beekman, Marian; Blanché, Hélène; Christensen, Kaare; Christiansen, Lene; Collerton, Joanna; Cubaynes, Sarah; R. Cummings, Steven; Davies, Karen; Debrabant, Birgit; Deleuze, Jean‐François; Duncan, Rachel; D. Faul, Jessica; Franceschi, Claudio; Galán, Pilar; Guðnason, Vilmundur; B. Harris, Tamara; Huisman, Martijn; Hurme, Mikko; Jagger, Carol; E. Jansen, Iris; Jylhä, Marja; Kähönen, Mika; Karasik, David; L. R. Kardia, Sharon; Kingston, Andrew; B. L. Kirkwood, Thomas; J. Launer, Lenore; Lehtimäki, Terho; Lieb, Wolfgang; Lyytikäinen, Leo‐Pekka; Martín-Ruiz, Carmen; Min, Junxia; Nebel, Almut; B. Newman, Anne; Nie, Chao; A. Nøhr, Ellen; Orwoll, Eric; T. Perls, Thomas; A. Province, Michael; M. Psaty, Bruce; Raitakari, Olli; Reinders, Marcel; Robine, Jean‐Marie; I. Rotter, Jerome; Sebastiani, Paola; A. Smith, Jennifer; I. A. Sørensen, Thorkild; D. Taylor, Kent; G. Uitterlinden, André; M. van der Flier, Wiesje; J. van der Lee, Sven; M. van Duijn, Cornelia; van Heemst, Diana; W. Vaupel, James; R. Weir, David; Ye, Kenny; Zeng, Yi; Zheng, Wanlin; Holstege, Henne; P. Kiel, Douglas; L. Lunetta, Kathryn; Eline Slagboom, P.; M. Murabito, Joanne

doi:10.1038/s41467-019-11558-2

Public

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Published in Nature Communications • Aug 14, 2019

Authors:

Joris Deelen

Daniel S. Evans

Dan E. Arking

Abstract

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percenti...

Subject

Longevity

Genome-wide association study

Genome

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